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Talin carries mechanical force (of 7-10 piconewton) during cell adhesion. It also allows cells to measure extracellular rigidity, since cells in which talin is prevented from forming mechanical linkages can no …

Talin (herein referring to the talin-1 form), is a cytoskeletal adapter protein that binds integrin receptors and F-actin, and is a key factor in the formation and regulation of integrin-dependent cell–matrix …

Talin is a protein that serves as a physical and informational link between a cell’s internal structure and its external environment. Discovered in 1983, it is found in high concentrations where cells attach to …

Talin is a cytoplasmic adapter protein capable of directly connecting integrins to the actin cytoskeleton. Talin consists of an N-terminal head domain (~residues 1–430) responsible for integrin binding, …

Nov 30, 2023 · Although talin is a key factor that translates mechanical forces into chemical responses primarily at sites of cell-matrix and cell-cell junctions, talin may also function in other cellular …

Oct 28, 2024 · Talin regulates crucial cellular functions, including cell adhesion and motility, and affects human diseases. Triggered by mechanical forces, talin plays crucial roles in facilitating the...

Aug 1, 2017 · Talin forms the core of integrin adhesion complexes by linking integrins directly to actin, increasing the affinity of integrin for ligands (integrin activation) and recruiting numerous proteins.

Aug 1, 2017 · Talin forms the core of integrin adhesion complexes by linking integrins directly to actin, increasing the affinity of integrin for ligands (integrin activation) and recruiting numerous proteins.

Feb 10, 2026 · A collaborative project between the Tanentzapf and Kim labs investigated how the disruption of talin regulation affects platelets and hemostasis 1.