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The new science of DNA’s hidden rules
Scientists are uncovering a deeper layer of DNA biology—where its shape, stiffness, and 3D organization are just as important as its sequence. New tools are mapping how replication starts, how damage ...
In a new study, scientists analyzed one such strategy used by the bacterium Escherichia coli. One of the enzymes in the ...
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This RNA almost self-replicates, which could explain life's origins
(Christoph Burgstedt/iStock/Getty Images Plus) The RNA world hypothesis posits that molecules made up of ribonucleic acids (RNA) are responsible for kickstarting evolution and all life on Earth – and ...
Scientists have found that DNA polymerases can write long, structured stretches of new genetic material without any template to copy. That finding reframes a long-known but overlooked behavior as a ...
Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...
DNA replication is a semi-conservative process in which half of the newly synthesized strands (daughters) are derived from the original strands (mothers). The confirmation of semi-conservative ...
This valuable paper describes the crystal structure of a complex of the Sld3-Cdc45-binding domain (CBD) with Cdc45, which is essential for the assembly of an active Cdc45-MCM-GINS (CMG) double-hexamer ...
The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...
Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer. Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss ...
Their role in DNA replication, repair, and targeted therapies highlights their growing importance in medical research and molecular diagnostics. As new innovations emerge, the global ligase market ...
Image for representation purpose only. Using cutting-edge cryo-electron microscopy, scientists at the University of Leicester have captured the first detailed “molecular movie” showing DNA being ...
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