Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia. How this happens remains largely ...

New research from Oregon Health & Science University for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications ...

Astrocytes use the MEGF10 receptor to prune synapses in the striatum, a process essential for dopamine-driven motor learning.

An interdisciplinary team of scientists at the Max Planck Florida Institute for Neuroscience have developed a novel approach to measure the activity and strength of individual synapses that drive a ...

The death of synapses, and the neurons that need them, marks the inevitable endgame of Alzheimer’s disease. Despite this eventual synaptic mayhem, a new work, led by Thomas Südhof and Marius Wernig at ...

Family with sequence similarity 19 member A5 (FAM19A5) is a secretory protein highly expressed in the brain that regulates synapse dynamics through its interaction with leucine-rich repeat-containing ...

A discovery could pave the way for future studies aimed at developing solutions to ALS and other vexing neuromuscular diseases. While the brain is composed of two types of cells, glia tend to receive ...