Cancer biology increasingly recognizes that cancer stem cells (CSCs) represent a critical subpopulation within tumors, marked by their self-renewal, ...

Outcomes of myeloid malignancies in patients previously treated with PARP inhibitors for solid malignancies: A single institution experience. This is an ASCO Meeting Abstract from the 2023 ASCO Annual ...

Scientists at the University of Pittsburgh, together with colleagues at the University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, have identified how a long ...

Epigenetics is the study of heritable changes in gene expression that do not involve alterations to the underlying DNA sequence. These changes can significantly impact gene activity and cellular ...

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function. Epigenetic features are just one way that cells control gene expression, ...

Our genes contain all the instructions our body needs to function, but their expression must be finely regulated to guarantee that each cell performs its role optimally. This is where DNA and RNA ...

Scientists have identified an RNA-based sperm aging clock driven by rsRNA length changes, which may help assess paternal reproductive risk and offspring health.

This article explains how diet creates sustained epigenetic changes that affect long-term health, disease risk, aging, and ...