Imagine trying to design a key for a lock that is constantly changing its shape. That is the exact challenge we face in modern drug discovery when dealing with intrinsically disordered proteins.

Intrinsically disordered proteins lack a fixed structure, which is why they have been considered "undruggable" targets for ...

RIKEN researchers have discovered how an enzyme modifies gene expression by targeting certain stretches of messenger RNA ...

Nicoya Lifesciences, Inc., a leading provider of advanced biophysical characterization tools for biologics discovery and development, today announced the launch of FastHDX, a new hydrogen-deuterium ...

Protein dynamics and intrinsic disorder represent a paradigm shift in our understanding of protein structure and function. Rather than depending solely on a single stable three‐dimensional structure, ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

A DGIST research team led by Prof. Yoo Wookyung (Department of Brain Sciences) and Prof. Kim Jin Hae (Department of New Biology) developed an innovative analytical technology in collaboration with a ...

Intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their ...

Intrinsically disordered proteins (IDPs) make up about 30 percent of our proteome. They are important to many fundamental aspects of biology and disrupted in disease. Since they lack a stable shape, ...

In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins with specific functions, from antibodies to blood clotting agents, by using ...

Researchers at Harvard and Northwestern have developed a machine learning method that can design intrinsically disordered proteins with custom properties, addressing nearly 30% of all human proteins ...