The complement system is activated in many rheumatic diseases, as evident from deposition of activation fragments in affected tissue, decreased residual complement function and increased levels of ...

Interleukin (IL)-8 production by human polymorphonuclear leukocytes (PMNL) to Cryptococcus neoformans is related to complement activation. Generation of the bioactive fragments C3a and C5a is ...

Please provide your email address to receive an email when new articles are posted on . Meningococcal vaccination rates are low among eligible patients with complement component deficiencies, ...

What can be done in the face of the analytic challenges? One practical solution is a step-wise progression, starting with well-accepted genetic risk factors that are paired with established or ...

The susceptibility of adopted children to infection correlates more with the susceptibility of their biologic parents than with that of their adoptive parents. 1 This suggests that genetic factors can ...

Studies of monogenic gastrointestinal diseases have revealed molecular pathways critical to gut homeostasis and enabled the development of targeted therapies. We studied 11 patients with abdominal ...

Severe Combined Immune Deficiency (SCID) T cell disorders Common Variable Immune Deficiency (CVID) Antibody deficiency diseases, and complement deficiencies Faculty research interests include the role ...

1. Facility is lacking in appointing a designated, qualified professional with training in infection prevention to direct the infection prevention program. This deficiency is most commonly cited in ...