When myelin breaks down, white matter in the brain deteriorates, a change commonly seen with aging. At the same time, microglia, the brain’s primary immune cells, can shift from protective responders ...

Scientists at City of Hope and the Broad Institute and Keio University have discovered how specific gut bacteria work ...

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study led by ...

The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling ...

After treatment, the mice’s memories were essentially shunted back into a younger state. The researchers found that reprogrammed engrams displayed molecular behavior of more youthful cells. Using a ...